6VIE

Structure of caspase-1 in complex with gasdermin D

Summary for 6VIE

Entry DOI	10.2210/pdb6vie/pdb
Descriptor	Caspase-1 subunit p20, Caspase-1 subunit p10, Gasdermin-D (3 entities in total)
Functional Keywords	dual site recognition, immune system
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	133602.20
Authors	Liu, Z.,Xiao, T.S. (deposition date: 2020-01-13, release date: 2020-07-01, Last modification date: 2023-10-11)
Primary citation	Liu, Z.,Wang, C.,Yang, J.,Chen, Y.,Zhou, B.,Abbott, D.W.,Xiao, T.S. Caspase-1 Engages Full-Length Gasdermin D through Two Distinct Interfaces That Mediate Caspase Recruitment and Substrate Cleavage. Immunity, 53:106-, 2020 Cited by PubMed: 32553275 DOI: 10.1016/j.immuni.2020.06.007 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.4 Å)

Structure validation