6VH4
Wild type EGFR in complex with LN2380
Summary for 6VH4
| Entry DOI | 10.2210/pdb6vh4/pdb |
| Descriptor | Epidermal growth factor receptor, N-[3-({4-[4-(4-fluorophenyl)-2-(3-hydroxypropyl)-1H-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide (3 entities in total) |
| Functional Keywords | epidermal growth factor receptor, inhibitor, cancer, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 37793.67 |
| Authors | Heppner, D.E.,Eck, M.J. (deposition date: 2020-01-09, release date: 2020-04-22, Last modification date: 2023-10-11) |
| Primary citation | Heppner, D.E.,Gunther, M.,Wittlinger, F.,Laufer, S.A.,Eck, M.J. Structural Basis for EGFR Mutant Inhibition by Trisubstituted Imidazole Inhibitors. J.Med.Chem., 63:4293-4305, 2020 Cited by PubMed: 32243152DOI: 10.1021/acs.jmedchem.0c00200 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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