6VGF

Peanut lectin complexed with divalent S-beta-D-thiogalactopyranosyl beta-D-glucopyranoside derivative (diSTGD)

Summary for 6VGF

• Entry DOI: 10.2210/pdb6vgf/pdb
• Descriptor: Galactose-binding lectin, (2S,3R,4S,5R,6S)-2-(hydroxymethyl)-6-{[(2S,3R,4S,5S,6S)-3,4,5-trihydroxy-6-({[(1-{[(2R,3S,4S,5R,6R)-3,4,5-trihydroxy-6-{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-({4-[({[(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-{[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]sulfanyl}tetrahydro-2H-pyran-2-yl]methyl}sulfanyl)methyl]-1H-1,2,3-triazol-1-yl}methyl)tetrahydro-2H-pyran-2-yl]oxy}tetrahydro-2H-pyran-2-yl]methyl}-1H-1,2,3-triazol-4-yl)methyl]sulfanyl}methyl)tetrahydro-2H-pyran-2-yl]sulfanyl}tetrahydro-2H-pyran-3,4,5-triol, MANGANESE (II) ION, ... (5 entities in total)
• Functional Keywords: beta-galactosylamides, beta-thiogalactosides, peanut agglutinin, glycomimetics, sugar binding protein
• Biological source: Arachis hypogaea (Peanut)
• Total number of polymer chains: 4
• Total formula weight: 106084.98

Authors

Otero, L.H.,Primo, E.D.,Cagnoni, A.J.,Cano, M.E.,Klinke, S.,Goldbaum, F.A.,Uhrig, M.L. (deposition date: 2020-01-08, release date: 2020-10-28, Last modification date: 2023-10-11)

• Primary citation: Cagnoni, A.J.,Primo, E.D.,Klinke, S.,Cano, M.E.,Giordano, W.,Marino, K.V.,Kovensky, J.,Goldbaum, F.A.,Uhrig, M.L.,Otero, L.H.; Crystal structures of peanut lectin in the presence of synthetic beta-N- and beta-S-galactosides disclose evidence for the recognition of different glycomimetic ligands.; Acta Crystallogr D Struct Biol, 76:1080-1091, 2020; PubMed: 33135679; DOI: 10.1107/S2059798320012371

Experimental method

X-RAY DIFFRACTION (1.83 Å)