6VDM

HCV NS3/4A protease A156T, D168E double mutant in complex with glecaprevir

Summary for 6VDM

• Entry DOI: 10.2210/pdb6vdm/pdb
• Descriptor: Non-structural protein 4A, Serine protease NS3, ZINC ION, Glecaprevir, ... (6 entities in total)
• Functional Keywords: hcv protease, ns34a protease, glecaprevir, viral protein, hydrolase
• Biological source: Hepatitis C virus genotype 1a (isolate 1) (HCV); More
• Total number of polymer chains: 1
• Total formula weight: 22848.00

Authors

Timm, J.,Schiffer, C.A. (deposition date: 2019-12-27, release date: 2020-12-30, Last modification date: 2025-01-29)

• Primary citation: Timm, J.,Zephyr, J.,Hou, S.,Kurt Yilmaz, N.,Schiffer, C.A.; RAS at position 156 of HCV NS3/4A protease abolish inhibition by current HCV drugs; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.9 Å)