6VCB

Cryo-EM structure of the Glucagon-like peptide-1 receptor in complex with G protein, GLP-1 peptide and a positive allosteric modulator

Summary for 6VCB

• Entry DOI: 10.2210/pdb6vcb/pdb
• EMDB information: 21147
• Descriptor: Glucagon-like peptide 1 receptor, Glucagon-like peptide 1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... (7 entities in total)
• Functional Keywords: g protein-coupled receptor, membrane protein, family b gpcr, diabetes, allosteric modulator, signaling protein-membrane protein complex, signaling protein/membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 163147.10

Authors

Sun, B.,Feng, D.,Bueno, A.,Kobilka, B.,Sloop, K. (deposition date: 2019-12-20, release date: 2020-07-22, Last modification date: 2020-09-30)

• Primary citation: Bueno, A.B.,Sun, B.,Willard, F.S.,Feng, D.,Ho, J.D.,Wainscott, D.B.,Showalter, A.D.,Vieth, M.,Chen, Q.,Stutsman, C.,Chau, B.,Ficorilli, J.,Agejas, F.J.,Cumming, G.R.,Jimenez, A.,Rojo, I.,Kobilka, T.S.,Kobilka, B.K.,Sloop, K.W.; Structural insights into probe-dependent positive allosterism of the GLP-1 receptor.; Nat.Chem.Biol., 16:1105-1110, 2020; PubMed: 32690941; DOI: 10.1038/s41589-020-0589-7

Experimental method

ELECTRON MICROSCOPY (3.3 Å)