6VBI
crystal structure of PDE5 in complex with a non-competitive inhibitor
Summary for 6VBI
Entry DOI | 10.2210/pdb6vbi/pdb |
Descriptor | cGMP-specific 3',5'-cyclic phosphodiesterase, (13bS)-4,9-dimethoxy-14-methyl-8,13,13b,14-tetrahydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one (3 entities in total) |
Functional Keywords | pde5, allosteric regulation, non-competitive inhibitors, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 76047.62 |
Authors | |
Primary citation | Zhang, T.,Ke, H.,Luo, H. Identification of a novel allosteric pocket and its regulation mechanism To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.30000752706 Å) |
Structure validation
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