6VBI

crystal structure of PDE5 in complex with a non-competitive inhibitor

6VBI の概要

• エントリーDOI: 10.2210/pdb6vbi/pdb
• 分子名称: cGMP-specific 3',5'-cyclic phosphodiesterase, (13bS)-4,9-dimethoxy-14-methyl-8,13,13b,14-tetrahydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one (3 entities in total)
• 機能のキーワード: pde5, allosteric regulation, non-competitive inhibitors, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 76047.62

構造登録者

Ke, H.,Luo, H.B. (登録日: 2019-12-18, 公開日: 2021-01-20, 最終更新日: 2023-10-11)

• 主引用文献: Zhang, T.,Ke, H.,Luo, H.; Identification of a novel allosteric pocket and its regulation mechanism; To Be Published,

実験手法

X-RAY DIFFRACTION (2.30000752706 Å)