6VBH

Human XPG endonuclease catalytic domain

6VBH の概要

• エントリーDOI: 10.2210/pdb6vbh/pdb
• 分子名称: DNA repair protein complementing XP-G cells,Flap endonuclease 1, SULFATE ION (3 entities in total)
• 機能のキーワード: metalloprotein, replication, dna damage, dna repair, nucloetide excision repair, xpg, xeroderma pigmentosum, 5' nuclease, hydrolase-dna complex, dna binding protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41561.82

構造登録者

Tsutakawa, S.E.,Arvai, A.S.,Tainer, J.A. (登録日: 2019-12-18, 公開日: 2020-06-17, 最終更新日: 2023-10-11)

• 主引用文献: Tsutakawa, S.E.,Sarker, A.H.,Ng, C.,Arvai, A.S.,Shin, D.S.,Shih, B.,Jiang, S.,Thwin, A.C.,Tsai, M.S.,Willcox, A.,Her, M.Z.,Trego, K.S.,Raetz, A.G.,Rosenberg, D.,Bacolla, A.,Hammel, M.,Griffith, J.D.,Cooper, P.K.,Tainer, J.A.; Human XPG nuclease structure, assembly, and activities with insights for neurodegeneration and cancer from pathogenic mutations.; Proc.Natl.Acad.Sci.USA, 117:14127-14138, 2020; PubMed: 32522879; DOI: 10.1073/pnas.1921311117

実験手法

X-RAY DIFFRACTION (1.995 Å)