6VB9
Covalent adduct of cis-2,3-epoxysuccinic acid with Isocitrate Lyase-1 from Mycobacterium tuberculosis
Summary for 6VB9
| Entry DOI | 10.2210/pdb6vb9/pdb |
| Descriptor | Isocitrate lyase, MAGNESIUM ION, OXALIC ACID, ... (6 entities in total) |
| Functional Keywords | enzyme, covalent inhibitor, substrate analog, structural genomics, psi-biology, tb structural genomics consortium, tbsgc, lyase |
| Biological source | Mycobacterium tuberculosis |
| Total number of polymer chains | 4 |
| Total formula weight | 191477.95 |
| Authors | Krieger, I.V.,Pham, T.V.,Meek, T.D.,Sacchettini, J.C.,TB Structural Genomics Consortium (TBSGC) (deposition date: 2019-12-18, release date: 2020-12-30, Last modification date: 2023-10-11) |
| Primary citation | Pham, T.V.,Mellott, D.M.,Moghadamchargari, Z.,Chen, K.,Krieger, I.,Laganowsky, A.,Sacchettini, J.C.,Meek, T.D. Covalent Inactivation of Mycobacterium tuberculosis Isocitrate Lyase by cis -2,3-Epoxy-Succinic Acid. Acs Chem.Biol., 16:463-470, 2021 Cited by PubMed: 33688722DOI: 10.1021/acschembio.0c00740 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.881 Å) |
Structure validation
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