6V9C
Crystal structure of FGFR4 kinase domain in complex with covalent inhibitor
Summary for 6V9C
Entry DOI | 10.2210/pdb6v9c/pdb |
Descriptor | Fibroblast growth factor receptor 4, N-[(3R,4S)-4-{[6-(2,6-dichloro-3,5-dimethoxyphenyl)-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl]amino}oxolan-3-yl]prop-2-enamide, SULFATE ION, ... (4 entities in total) |
Functional Keywords | tyrosine kinase inhibitor, covalent inhibitor, fgfr, kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 34579.70 |
Authors | |
Primary citation | Liu, H.,Niu, D.,Tham Sjin, R.T.,Dubrovskiy, A.,Zhu, Z.,McDonald, J.J.,Fahnoe, K.,Wang, Z.,Munson, M.,Scholte, A.,Barrague, M.,Fitzgerald, M.,Liu, J.,Kothe, M.,Sun, F.,Murtie, J.,Ge, J.,Rocnik, J.,Harvey, D.,Ospina, B.,Perron, K.,Zheng, G.,Shehu, E.,D'Agostino, L.A. Discovery of Selective, Covalent FGFR4 Inhibitors with Antitumor Activity in Models of Hepatocellular Carcinoma. Acs Med.Chem.Lett., 11:1899-1904, 2020 Cited by PubMed: 33062171DOI: 10.1021/acsmedchemlett.9b00601 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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