6V8K
Crystal structure of the p300 acetyltransferase domain with peptide-competitive inhibitor 2
Summary for 6V8K
Entry DOI | 10.2210/pdb6v8k/pdb |
Related | 6V8B |
Descriptor | Histone acetyltransferase p300, COENZYME A, 1-(2-methyl-1H-indol-3-yl)-2-[(2R)-2-methylpiperidin-1-yl]ethan-1-one, ... (5 entities in total) |
Functional Keywords | epigenetics, chromatin, writer, transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 1 |
Total formula weight | 38301.52 |
Authors | Gardberg, A.S. (deposition date: 2019-12-11, release date: 2020-04-01, Last modification date: 2024-04-03) |
Primary citation | Huhn, A.J.,Gardberg, A.S.,Poy, F.,Brucelle, F.,Vivat, V.,Cantone, N.,Patel, G.,Patel, C.,Cummings, R.,Sims, R.,Levell, J.,Audia, J.E.,Bommi-Reddy, A.,Wilson, J.E. Early Drug-Discovery Efforts towards the Identification of EP300/CBP Histone Acetyltransferase (HAT) Inhibitors. Chemmedchem, 15:955-960, 2020 Cited by PubMed: 32181984DOI: 10.1002/cmdc.202000007 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.84 Å) |
Structure validation
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