6V8D

Design, Synthesis, and Mechanism of Fluorine-substituted Cyclohexene Analogues of GAMA-Aminobutyric Acid (GABA) as Selective Ornithine Aminotransferase Inactivators

Summary for 6V8D

• Entry DOI: 10.2210/pdb6v8d/pdb
• Descriptor: Ornithine aminotransferase, mitochondrial, PYRIDOXAL-5'-PHOSPHATE, (3Z)-3-iminocyclohex-1-ene-1-carboxylic acid, ... (4 entities in total)
• Functional Keywords: human ornithine aminotransferase (hoat), mechanism based inactivator, plp hepatocellular carcinoma (hcc), transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 3
• Total formula weight: 135739.84

Authors

Zhu, W.,Doubleday, P.T.,Catlin, D.S.,Weerawarna, P.,Butrin, A.,Shen, S.,Kelleher, N.L.,Liu, D.,Silverman, R.B. (deposition date: 2019-12-10, release date: 2020-12-16, Last modification date: 2023-10-11)

• Primary citation: Zhu, W.,Doubleday, P.T.,Catlin, D.S.,Weerawarna, P.,Butrin, A.,Shen, S.,Kelleher, N.L.,Liu, D.,Silverman, R.B.; Design, Synthesis, and Mechanism of Fluorine-substituted Cyclohexene Analogues of GAMA-Aminobutyric Acid (GABA) as Selective Ornithine Aminotransferase Inactivators; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.25 Å)