6V8D

Design, Synthesis, and Mechanism of Fluorine-substituted Cyclohexene Analogues of GAMA-Aminobutyric Acid (GABA) as Selective Ornithine Aminotransferase Inactivators

6V8D の概要

• エントリーDOI: 10.2210/pdb6v8d/pdb
• 分子名称: Ornithine aminotransferase, mitochondrial, PYRIDOXAL-5'-PHOSPHATE, (3Z)-3-iminocyclohex-1-ene-1-carboxylic acid, ... (4 entities in total)
• 機能のキーワード: human ornithine aminotransferase (hoat), mechanism based inactivator, plp hepatocellular carcinoma (hcc), transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 135739.84

構造登録者

Zhu, W.,Doubleday, P.T.,Catlin, D.S.,Weerawarna, P.,Butrin, A.,Shen, S.,Kelleher, N.L.,Liu, D.,Silverman, R.B. (登録日: 2019-12-10, 公開日: 2020-12-16, 最終更新日: 2023-10-11)

• 主引用文献: Zhu, W.,Doubleday, P.T.,Catlin, D.S.,Weerawarna, P.,Butrin, A.,Shen, S.,Kelleher, N.L.,Liu, D.,Silverman, R.B.; Design, Synthesis, and Mechanism of Fluorine-substituted Cyclohexene Analogues of GAMA-Aminobutyric Acid (GABA) as Selective Ornithine Aminotransferase Inactivators; To Be Published,

実験手法

X-RAY DIFFRACTION (2.25 Å)