6V7N

Crystal Structure of a human Lysosome Resident Glycoprotein, Lysosomal Acid Lipase, and its Implications in Cholesteryl Ester Storage Disease (CESD)

6V7N の概要

• エントリーDOI: 10.2210/pdb6v7n/pdb
• 分子名称: Lysosomal acid lipase/cholesteryl ester hydrolase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: lysosomal acid lipase, cholesteryl ester storage disease, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 89239.68

構造登録者

Han, S. (登録日: 2019-12-09, 公開日: 2020-06-17, 最終更新日: 2023-10-11)

• 主引用文献: Rajamohan, F.,Reyes, A.R.,Tu, M.,Nedoma, N.L.,Hoth, L.R.,Schwaid, A.G.,Kurumbail, R.G.,Ward, J.,Han, S.; Crystal structure of human lysosomal acid lipase and its implications in cholesteryl ester storage disease.; J.Lipid Res., 61:1192-1202, 2020; PubMed: 32482718; DOI: 10.1194/jlr.RA120000748

実験手法

X-RAY DIFFRACTION (2.62 Å)