6V7C
Human Arginase1 Complexed with Bicyclic Inhibitor Compound 3
6V7C の概要
エントリーDOI | 10.2210/pdb6v7c/pdb |
分子名称 | Arginase-1, MANGANESE (II) ION, {3-[(3aR,4S,5S,6aR)-5-azaniumyl-5-carboxyoctahydrocyclopenta[c]pyrrol-2-ium-4-yl]propyl}(trihydroxy)borate(1-), ... (4 entities in total) |
機能のキーワード | agonist, arg (arginase), bicyclic, immunotherapy, metalloenzyme, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 6 |
化学式量合計 | 210989.31 |
構造登録者 | |
主引用文献 | Mitcheltree, M.J.,Li, D.,Achab, A.,Beard, A.,Chakravarthy, K.,Cheng, M.,Cho, H.,Eangoor, P.,Fan, P.,Gathiaka, S.,Kim, H.Y.,Lesburg, C.A.,Lyons, T.W.,Martinot, T.A.,Miller, J.R.,McMinn, S.,O'Neil, J.,Palani, A.,Palte, R.L.,Sauri, J.,Sloman, D.L.,Zhang, H.,Cumming, J.N.,Fischer, C. Discovery and Optimization of Rationally Designed Bicyclic Inhibitors of Human Arginase to Enhance Cancer Immunotherapy. Acs Med.Chem.Lett., 11:582-588, 2020 Cited by PubMed: 32292567DOI: 10.1021/acsmedchemlett.0c00058 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.8 Å) |
構造検証レポート
検証レポート(詳細版)をダウンロード