6V62

SETD3 double mutant (N255F/W273A) in Complex with an Actin Peptide with His73 Replaced with Lysine

Summary for 6V62

Entry DOI	10.2210/pdb6v62/pdb
Descriptor	Actin, cytoplasmic 1, Actin-histidine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, ... (5 entities in total)
Functional Keywords	transferase, transferase-structural protein complex, transferase/structural protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	70958.15
Authors	Dai, S.,Horton, J.R.,Cheng, X. (deposition date: 2019-12-04, release date: 2020-01-15, Last modification date: 2023-10-11)
Primary citation	Dai, S.,Horton, J.R.,Wilkinson, A.W.,Gozani, O.,Zhang, X.,Cheng, X. An engineered variant of SETD3 methyltransferase alters target specificity from histidine to lysine methylation. J.Biol.Chem., 295:2582-2589, 2020 Cited by PubMed: 31911441 DOI: 10.1074/jbc.RA119.012319 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.36 Å)

Structure validation