6V34
Crystal structure of BRAF V600E oncogenic mutant in complex with TAK-580
Summary for 6V34
Entry DOI | 10.2210/pdb6v34/pdb |
Descriptor | Serine/threonine-protein kinase B-raf, 6-amino-5-chloro-N-[(1R)-1-(5-{[5-chloro-4-(trifluoromethyl)pyridin-2-yl]carbamoyl}-1,3-thiazol-2-yl)ethyl]pyrimidine-4-carboxamide (2 entities in total) |
Functional Keywords | braf, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 65101.91 |
Authors | Gonzalez Del-Pino, G.,Li, K.,Eck, M.J. (deposition date: 2019-11-25, release date: 2020-12-02, Last modification date: 2023-10-11) |
Primary citation | Gonzalez Del-Pino, G.,Li, K.,Eck, M.J. Crystal structure of BRAF V600E oncogenic mutant in complex with TAK-580 To Be Published, |
Experimental method | X-RAY DIFFRACTION (3.15 Å) |
Structure validation
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