6V27
Complex of double mutant (T89V,K162T) of E. coli L-asparaginase II with L-Asp
Summary for 6V27
| Entry DOI | 10.2210/pdb6v27/pdb |
| Descriptor | L-asparaginase 2 (2 entities in total) |
| Functional Keywords | l-asparagine hydrolase, anti-cancer drug, inactive mutant, hydrolase |
| Biological source | Escherichia coli (strain K12) |
| Total number of polymer chains | 4 |
| Total formula weight | 142687.66 |
| Authors | Lubkowski, J.,Wlodawer, A. (deposition date: 2019-11-22, release date: 2020-05-20, Last modification date: 2023-10-11) |
| Primary citation | Lubkowski, J.,Vanegas, J.,Chan, W.K.,Lorenzi, P.L.,Weinstein, J.N.,Sukharev, S.,Fushman, D.,Rempe, S.,Anishkin, A.,Wlodawer, A. Mechanism of Catalysis by l-Asparaginase. Biochemistry, 59:1927-1945, 2020 Cited by PubMed: 32364696DOI: 10.1021/acs.biochem.0c00116 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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