6V08

Crystal structure of human recombinant Beta-2 glycoprotein I (hrB2GPI)

6V08 の概要

• エントリーDOI: 10.2210/pdb6v08/pdb
• 関連するPDBエントリー: 1C1Z
• 分子名称: Beta-2-glycoprotein 1, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: plasma glycoprotein, coagulation, innate immune system, autoimmunity, thrombosis, sushi domain, blood clotting
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41746.27

構造登録者

Chen, Z.,Ruben, E.A.,Planer, W.,Chinnaraj, M.,Zuo, X.,Pengo, V.,Macor, P.,Tedesco, F.,Pozzi, N. (登録日: 2019-11-18, 公開日: 2020-06-17, 最終更新日: 2023-10-11)

• 主引用文献: Ruben, E.,Planer, W.,Chinnaraj, M.,Chen, Z.,Zuo, X.,Pengo, V.,De Filippis, V.,Alluri, R.K.,McCrae, K.R.,Macor, P.,Tedesco, F.,Pozzi, N.; The J-elongated conformation of beta2-glycoprotein I predominates in solution: implications for our understanding of antiphospholipid syndrome.; J.Biol.Chem., 295:10794-10806, 2020; PubMed: 32518155; DOI: 10.1074/jbc.RA120.013939

実験手法

X-RAY DIFFRACTION (2.58 Å)