6UYG

Structure of Hepatitis C Virus Envelope Glycoprotein E2c3 core from genotype 6a bound to broadly neutralizing antibody AR3A and non neutralizing antibody E1

Summary for 6UYG

Entry DOI	10.2210/pdb6uyg/pdb
Descriptor	Envelope glycoprotein E2, Fab AR3A heavy chain, Fab AR3A light chain, ... (8 entities in total)
Functional Keywords	hcv, e2 core, vaccine design, self-assembly nanoparticle, broadly neutralizing antibodies, bnabs, immune system
Biological source	Recombinant Hepatitis C virus HK6a/JFH-1 More
Total number of polymer chains	6
Total formula weight	124099.51
Authors	Tzarum, N.,Wilson, I.A.,Zhu, J. (deposition date: 2019-11-13, release date: 2020-04-22, Last modification date: 2023-10-11)
Primary citation	He, L.,Tzarum, N.,Lin, X.,Shapero, B.,Sou, C.,Mann, C.J.,Stano, A.,Zhang, L.,Nagy, K.,Giang, E.,Law, M.,Wilson, I.A.,Zhu, J. Proof of concept for rational design of hepatitis C virus E2 core nanoparticle vaccines. Sci Adv, 6:eaaz6225-eaaz6225, 2020 Cited by PubMed: 32494617 DOI: 10.1126/sciadv.aaz6225 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.375 Å)

Structure validation