6UYB

Crystal structure of TEAD2 bound to Compound 1

Summary for 6UYB

• Entry DOI: 10.2210/pdb6uyb/pdb
• Descriptor: Transcriptional enhancer factor TEF-4, GLYCEROL, (3R,4R)-1-{3-[(E)-2-(4-chlorophenyl)ethenyl]-4-methoxy-5-methylphenyl}-3,4-dihydroxypyrrolidin-2-one, ... (5 entities in total)
• Functional Keywords: ead, yap binding domain, transcription inhibitor, palmitoylation inhibitor, transcription-transcription inhibitor complex, transcription/transcription inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 54368.17

Authors

Noland, C.L.,Holden, J.K.,Crawford, J.J.,Zbieg, J.R.,Cunningham, C.N. (deposition date: 2019-11-12, release date: 2020-06-24, Last modification date: 2023-10-11)

• Primary citation: Holden, J.K.,Crawford, J.J.,Noland, C.L.,Schmidt, S.,Zbieg, J.R.,Lacap, J.A.,Zang, R.,Miller, G.M.,Zhang, Y.,Beroza, P.,Reja, R.,Lee, W.,Tom, J.Y.K.,Fong, R.,Steffek, M.,Clausen, S.,Hagenbeek, T.J.,Hu, T.,Zhou, Z.,Shen, H.C.,Cunningham, C.N.; Small Molecule Dysregulation of TEAD Lipidation Induces a Dominant-Negative Inhibition of Hippo Pathway Signaling.; Cell Rep, 31:107809-107809, 2020; PubMed: 32579935; DOI: 10.1016/j.celrep.2020.107809

Experimental method

X-RAY DIFFRACTION (1.543 Å)