6UXY
PRMT5:MEP50 Complexed with Allosteric Inhibitor Compound 8
Summary for 6UXY
Entry DOI | 10.2210/pdb6uxy/pdb |
Related | 6UXX |
Descriptor | Protein arginine N-methyltransferase 5, Methylosome protein 50, (5R)-2-amino-5-(2-cyclohexylethyl)-3-methyl-5-phenyl-3,5-dihydro-4H-imidazol-4-one, ... (6 entities in total) |
Functional Keywords | methyltransferase, prmt5, protein arginine methyltransferase 5, allosteric inhibition, peptide competitive, sam competitive, transferase, transferase-transcription complex, transferase/transcription |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 112079.60 |
Authors | Palte, R.L.,Schneider, S.E. (deposition date: 2019-11-08, release date: 2020-08-19, Last modification date: 2023-10-11) |
Primary citation | Palte, R.L.,Schneider, S.E.,Altman, M.D.,Hayes, R.P.,Kawamura, S.,Lacey, B.M.,Mansueto, M.S.,Reutershan, M.,Siliphaivanh, P.,Sondey, C.,Xu, H.,Xu, Z.,Ye, Y.,Machacek, M.R. Allosteric Modulation of Protein Arginine Methyltransferase 5 (PRMT5). Acs Med.Chem.Lett., 11:1688-1693, 2020 Cited by PubMed: 32944135DOI: 10.1021/acsmedchemlett.9b00525 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.57 Å) |
Structure validation
Download full validation report