6UX9

Crystal Structure Analysis of PIP4K2A

6UX9 の概要

• エントリーDOI: 10.2210/pdb6ux9/pdb
• 分子名称: Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, N-[4-(5-{(Z)-[(2E)-2-imino-4-oxo-1,3-thiazolidin-5-ylidene]methyl}pyridin-3-yl)phenyl]methanesulfonamide (3 entities in total)
• 機能のキーワード: kinase, signaling protein, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 86490.21

構造登録者

Seo, H.-S.,Dhe-Paganon, S. (登録日: 2019-11-07, 公開日: 2020-12-09, 最終更新日: 2023-10-11)

• 主引用文献: Manz, T.D.,Sivakumaren, S.C.,Ferguson, F.M.,Zhang, T.,Yasgar, A.,Seo, H.S.,Ficarro, S.B.,Card, J.D.,Shim, H.,Miduturu, C.V.,Simeonov, A.,Shen, M.,Marto, J.A.,Dhe-Paganon, S.,Hall, M.D.,Cantley, L.C.,Gray, N.S.; Discovery and Structure-Activity Relationship Study of ( Z )-5-Methylenethiazolidin-4-one Derivatives as Potent and Selective Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors.; J.Med.Chem., 63:4880-4895, 2020; PubMed: 32298120; DOI: 10.1021/acs.jmedchem.0c00227

実験手法

X-RAY DIFFRACTION (1.71 Å)