6UWQ

Crystal structure of dihydrofolate reductase from Mycobacterium ulcerans with SDDC-0001565 inhibitor

6UWQ の概要

• エントリーDOI: 10.2210/pdb6uwq/pdb
• 分子名称: Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-(3-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)propanoic acid, ... (5 entities in total)
• 機能のキーワード: ssgcid, dhfr, structure-guided drug discovery coalition, structural genomics, seattle structural genomics center for infectious disease, oxidoreductase
• 由来する生物種: Mycobacterium ulcerans (strain Agy99)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 20263.57

構造登録者

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (登録日: 2019-11-05, 公開日: 2020-11-11, 最終更新日: 2023-10-11)

• 主引用文献: Mayclin, S.J.,Abendroth, J.A.,Lorimer, D.D.,Horanyi, P.S.,Edwards, T.E.; Crystal structure of dihydrofolate reductase from Mycobacterium ulcerans with SDDC-0001565 inhibitor; to be published,

実験手法

X-RAY DIFFRACTION (1.5 Å)