6UVE

Crystal structure of BCL-XL bound to compound 7: (R)-3-(Benzylthio)-2-(3-(4-chloro-[1,1':2',1'':3'',1'''-quaterphenyl]-4'''-carbonyl)-3-(4-methylbenzyl)ureido)propanoic acid

Summary for 6UVE

Entry DOI	10.2210/pdb6uve/pdb
Descriptor	Bcl-2-like protein 1, (R)-3-(Benzylthio)-2-(3-(4-chloro-[1,1':2',1'':3'',1'''-quaterphenyl]-4'''-carbonyl)-3-(4-methylbenzyl)ureido)propanoic acid, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	apoptosis, bcl-2 family, bcl-xl, inhibitor, apoptosis-inhibitor complex, apoptosis/inhibitor
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	55991.83
Authors	Roy, M.J.,Lessene, G.,Czabotar, P.E. (deposition date: 2019-11-02, release date: 2021-05-05, Last modification date: 2023-10-11)
Primary citation	Roy, M.J.,Vom, A.,Okamoto, T.,Smith, B.J.,Birkinshaw, R.W.,Yang, H.,Abdo, H.,White, C.A.,Segal, D.,Huang, D.C.S.,Baell, J.B.,Colman, P.M.,Czabotar, P.E.,Lessene, G. Structure-Guided Development of Potent Benzoylurea Inhibitors of BCL-X L and BCL-2. J.Med.Chem., 64:5447-5469, 2021 Cited by PubMed: 33904752 DOI: 10.1021/acs.jmedchem.0c01771 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.87 Å)

Structure validation