6UUO
Crystal structure of BRAF kinase domain bound to the PROTAC P4B
Summary for 6UUO
Entry DOI | 10.2210/pdb6uuo/pdb |
Descriptor | Serine/threonine-protein kinase B-raf, N-(3-{5-[(1-acetylpiperidin-4-yl)(methyl)amino]-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-1-yl}-2,4-difluorophenyl)propane-1-sulfonamide (3 entities in total) |
Functional Keywords | complex, protac, signaling, signaling protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 65667.19 |
Authors | Maisonneuve, P.,Posternak, G.,Kurinov, I.,Sicheri, F. (deposition date: 2019-10-30, release date: 2020-06-03, Last modification date: 2023-10-11) |
Primary citation | Posternak, G.,Tang, X.,Maisonneuve, P.,Jin, T.,Lavoie, H.,Daou, S.,Orlicky, S.,Goullet de Rugy, T.,Caldwell, L.,Chan, K.,Aman, A.,Prakesch, M.,Poda, G.,Mader, P.,Wong, C.,Maier, S.,Kitaygorodsky, J.,Larsen, B.,Colwill, K.,Yin, Z.,Ceccarelli, D.F.,Batey, R.A.,Taipale, M.,Kurinov, I.,Uehling, D.,Wrana, J.,Durocher, D.,Gingras, A.C.,Al-Awar, R.,Therrien, M.,Sicheri, F. Functional characterization of a PROTAC directed against BRAF mutant V600E. Nat.Chem.Biol., 16:1170-1178, 2020 Cited by PubMed: 32778845DOI: 10.1038/s41589-020-0609-7 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.288 Å) |
Structure validation
Download full validation report