6USA

Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate- and GSK1-bound form

6USA の概要

• エントリーDOI: 10.2210/pdb6usa/pdb
• 分子名称: Tryptophan synthase alpha chain, ACETATE ION, SULFATE ION, ... (13 entities in total)
• 機能のキーワード: plp, heterotetramer, amino acid biosynthesis, substrate channeling, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• 由来する生物種: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv); 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 293528.25

構造登録者

Chang, C.,Michalska, K.,Maltseva, N.I.,Jedrzejczak, R.,McCarren, P.,Nag, P.P.,Joachimiak, A.,Center for Structural Genomics of Infectious Diseases (CSGID) (登録日: 2019-10-25, 公開日: 2020-09-30, 最終更新日: 2023-10-25)

• 主引用文献: Michalska, K.,Chang, C.,Maltseva, N.I.,Jedrzejczak, R.,Robertson, G.T.,Gusovsky, F.,McCarren, P.,Schreiber, S.L.,Nag, P.P.,Joachimiak, A.; Allosteric inhibitors of Mycobacterium tuberculosis tryptophan synthase.; Protein Sci., 29:779-788, 2020; PubMed: 31930594; DOI: 10.1002/pro.3825

実験手法

X-RAY DIFFRACTION (2.406 Å)