6URV

Crystal structure of Yellow Fever Virus NS2B-NS3 protease domain

Summary for 6URV

• Entry DOI: 10.2210/pdb6urv/pdb
• Descriptor: NS2B, NS3 protease (3 entities in total)
• Functional Keywords: yellow fever, protease, ns3, flavivirus flaviviruses, yfv, peptide binding protein, viral protein
• Biological source: Yellow fever virus; More
• Total number of polymer chains: 8
• Total formula weight: 97524.26

Authors

Noske, G.D.,Gawriljuk, V.F.O.,Fernandes, R.S.,Oliva, G.,Godoy, A.S. (deposition date: 2019-10-24, release date: 2020-01-22, Last modification date: 2023-10-11)

Primary citation

Noske, G.D.,Gawriljuk, V.O.,Fernandes, R.S.,Furtado, N.D.,Bonaldo, M.C.,Oliva, G.,Godoy, A.S.
Structural characterization and polymorphism analysis of the NS2B-NS3 protease from the 2017 Brazilian circulating strain of Yellow Fever virus.
Biochim Biophys Acta Gen Subj, 1864:129521-129521, 2020

PubMed Abstract: The Yellow Fever virus (YFV) is transmitted by mosquitos and causes an infection with symptoms including fever, headaches and nausea. In 20-50% of the cases, the disease may evolve to a visceral stage, reaching high mortality rates. YFV NS2B-NS3 protease has been identified as an important drug target.

PubMed: 31931019
DOI: 10.1016/j.bbagen.2020.129521

Experimental method

X-RAY DIFFRACTION (2.9 Å)