6UQC
Mouse IgG2a Bispecific Fc
Summary for 6UQC
| Entry DOI | 10.2210/pdb6uqc/pdb |
| Descriptor | Ig gamma-2A chain C region, membrane-bound form, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total) |
| Functional Keywords | bispecific, electrostatic steering, fc, immune system |
| Biological source | Mus musculus (Mouse) More |
| Total number of polymer chains | 4 |
| Total formula weight | 100889.09 |
| Authors | Wang, F.,Tsai, J.C.,Davis, J.H.,West, S.M.,Strop, P. (deposition date: 2019-10-18, release date: 2020-01-01, Last modification date: 2024-11-13) |
| Primary citation | Wang, F.,Tsai, J.C.,Davis, J.H.,Chau, B.,Dong, J.,West, S.M.,Hogan, J.M.,Wheeler, M.L.,Bee, C.,Morishige, W.,Cayton, T.,David-Brown, D.,Zhang, C.,Kozhich, A.,Sproul, T.,Dollinger, G.,Rajpal, A.,Strop, P. Design and characterization of mouse IgG1 and IgG2a bispecific antibodies for use in syngeneic models. Mabs, 12:1685350-1685350, 2019 Cited by PubMed Abstract: The development of antibody therapeutics relies on animal models that accurately recapitulate disease biology. Syngeneic mouse models are increasingly used with new molecules to capture the biology of complex cancers and disease states, and to provide insight into the role of the immune system. The establishment of syngeneic mouse models requires the ability to generate surrogate mouse counterparts to antibodies designed for humans. In the field of bispecific antibodies, there remains a dearth of technologies available to generate native IgG-like mouse bispecific antibodies. Thus, we engineered a simple co-expression system for one-step purification of intact mouse IgG1 and IgG2a bispecific antibodies from any antibody pair. We demonstrated proof of concept with CD3/CD20 bispecific antibodies, which highlighted both the quality and efficacy of materials generated by this technology. PubMed: 31856660DOI: 10.1080/19420862.2019.1685350 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.87 Å) |
Structure validation
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