6UPX

RNA polymerase II elongation complex with 5-guanidinohydantoin lesion in state 1

6UPX の概要

• エントリーDOI: 10.2210/pdb6upx/pdb
• 分子名称: RNA, DNA-directed RNA polymerase II subunit RPB9, DNA-directed RNA polymerases I, II, and III subunit RPABC5, ... (15 entities in total)
• 機能のキーワード: rna polymerase ii, 5-guanidinohydantoin, elongation complex, dna lesion, transcription, transcription-rna-dna complex, transcription/rna/dna
• 由来する生物種: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast); 詳細
• タンパク質・核酸の鎖数: 13
• 化学式量合計: 487517.68

構造登録者

Oh, J.,Wang, D. (登録日: 2019-10-18, 公開日: 2020-06-10, 最終更新日: 2023-10-11)

• 主引用文献: Oh, J.,Fleming, A.M.,Xu, J.,Chong, J.,Burrows, C.J.,Wang, D.; RNA polymerase II stalls on oxidative DNA damage via a torsion-latch mechanism involving lone pair-pi and CH-pi interactions.; Proc.Natl.Acad.Sci.USA, 117:9338-9348, 2020; PubMed: 32284409; DOI: 10.1073/pnas.1919904117

実験手法

X-RAY DIFFRACTION (3.4 Å)