6UON

Molecular basis for tumor infiltrating TCR recognition of hotspot KRAS-G12D mutation

Summary for 6UON

• Entry DOI: 10.2210/pdb6uon/pdb
• Descriptor: TCR-V-alpha-12-02*01, TCR-V-beta-10-2*01, HLA class I antigen, ... (5 entities in total)
• Functional Keywords: hla-c neoantigen kras, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 10
• Total formula weight: 188492.86

Authors

Sun, P.D.,Sim, M.J.W. (deposition date: 2019-10-15, release date: 2020-05-27, Last modification date: 2023-10-11)

• Primary citation: Sim, M.J.W.,Lu, J.,Spencer, M.,Hopkins, F.,Tran, E.,Rosenberg, S.A.,Long, E.O.,Sun, P.D.; High-affinity oligoclonal TCRs define effective adoptive T cell therapy targeting mutant KRAS-G12D.; Proc.Natl.Acad.Sci.USA, 117:12826-12835, 2020; PubMed: 32461371; DOI: 10.1073/pnas.1921964117

Experimental method

X-RAY DIFFRACTION (3.5 Å)