6UOM
Y271G DNA polymerase beta ternary complex with templating adenine and incoming r8-oxo-GTP
Summary for 6UOM
Entry DOI | 10.2210/pdb6uom/pdb |
Descriptor | DNA (5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*G)-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ... (10 entities in total) |
Functional Keywords | dna polymerase, oxidized ribonucleotide, dna damage, dna binding protein, transferase-dna complex, transferase/dna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 48452.92 |
Authors | Smith, M.R.,Freudenthal, B.D. (deposition date: 2019-10-15, release date: 2020-01-08, Last modification date: 2023-10-11) |
Primary citation | Smith, M.R.,Alnajjar, K.S.,Hoitsma, N.M.,Sweasy, J.B.,Freudenthal, B.D. Molecular and structural characterization of oxidized ribonucleotide insertion into DNA by human DNA polymerase beta. J.Biol.Chem., 295:1613-1622, 2020 Cited by PubMed: 31892517DOI: 10.1074/jbc.RA119.011569 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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