6UO1

Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA (containing pseudouridine at the first position of the codon) and deacylated A-, P-, and E-site tRNAs at 2.95A resolution

This is a non-PDB format compatible entry.

Summary for 6UO1

• Entry DOI: 10.2210/pdb6uo1/pdb
• Descriptor: 23S Ribosomal RNA, 50S ribosomal protein L14, 50S ribosomal protein L15, ... (59 entities in total)
• Functional Keywords: pseudouridine, mrna, modification, ribosome, translation, peptidyl transferase center, trna accommodation
• Biological source: Thermus thermophilus HB8; More
• Total number of polymer chains: 112
• Total formula weight: 4537656.70

Authors

Batool, Z.,Dobosz-Bartoszek, M.,Polikanov, Y.S. (deposition date: 2019-10-14, release date: 2019-11-27, Last modification date: 2023-11-15)

• Primary citation: Eyler, D.E.,Franco, M.K.,Batool, Z.,Wu, M.Z.,Dubuke, M.L.,Dobosz-Bartoszek, M.,Jones, J.D.,Polikanov, Y.S.,Roy, B.,Koutmou, K.S.; Pseudouridinylation of mRNA coding sequences alters translation.; Proc.Natl.Acad.Sci.USA, 116:23068-23074, 2019; PubMed: 31672910; DOI: 10.1073/pnas.1821754116

Experimental method

X-RAY DIFFRACTION (2.95 Å)