6UMX

Structural basis for specific inhibition of extracellular activation of pro/latent myostatin by SRK-015

6UMX の概要

• エントリーDOI: 10.2210/pdb6umx/pdb
• 分子名称: Growth/differentiation factor 8, GL29H4-16 Fab Light Chain,GL29H4-16 Fab Light Chain, GL29H4-16 Fab Heavy Chain,GL29H4-16 Fab Heavy Chain, ... (5 entities in total)
• 機能のキーワード: myostatin, gdf8, transforming growth factor beta, muscle wasting disease, antibody, fab, signaling protein-immune system complex, signaling protein/immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 178140.31

構造登録者

Dagbay, K.B.,Treece, E.,Streich Jr., F.C.,Jackson, J.W.,Faucette, R.R.,Nikiforov, A.,Lin, S.C.,Bostion, C.J.,Nicholls, S.B.,Capili, A.D.,Carven, G.J. (登録日: 2019-10-10, 公開日: 2020-02-26, 最終更新日: 2023-10-11)

• 主引用文献: Dagbay, K.B.,Treece, E.,Streich Jr., F.C.,Jackson, J.W.,Faucette, R.R.,Nikiforov, A.,Lin, S.C.,Boston, C.J.,Nicholls, S.B.,Capili, A.D.,Carven, G.J.; Structural basis of specific inhibition of extracellular activation of pro- or latent myostatin by the monoclonal antibody SRK-015.; J.Biol.Chem., 295:5404-5418, 2020; PubMed: 32075906; DOI: 10.1074/jbc.RA119.012293

実験手法

X-RAY DIFFRACTION (2.79 Å)