6UML
Structural Basis for Thalidomide Teratogenicity Revealed by the Cereblon-DDB1-SALL4-Pomalidomide Complex
Summary for 6UML
Entry DOI | 10.2210/pdb6uml/pdb |
Descriptor | DNA damage-binding protein 1, Protein cereblon, Sal-like protein 4, ... (5 entities in total) |
Functional Keywords | celmod, cereblon-crl4, ubiquitin ligase, c2h2 zinc finger, ligase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 177358.87 |
Authors | Clayton, T.L.,Matyskiela, M.E.,Pagarigan, B.E.,Tran, E.T.,Chamberlain, P.P. (deposition date: 2019-10-09, release date: 2020-04-15, Last modification date: 2023-10-11) |
Primary citation | Matyskiela, M.E.,Clayton, T.,Zheng, X.,Mayne, C.,Tran, E.,Carpenter, A.,Pagarigan, B.,McDonald, J.,Rolfe, M.,Hamann, L.G.,Lu, G.,Chamberlain, P.P. Crystal structure of the SALL4-pomalidomide-cereblon-DDB1 complex. Nat.Struct.Mol.Biol., 27:319-322, 2020 Cited by PubMed: 32251415DOI: 10.1038/s41594-020-0405-9 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.58 Å) |
Structure validation
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