6UK1

Crystal structure of nucleotide-binding domain 2 (NBD2) of the human Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)

6UK1 の概要

• エントリーDOI: 10.2210/pdb6uk1/pdb
• 分子名称: Cystic fibrosis transmembrane conductance regulator, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: nbd2, cftr, abc transport, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 104335.13

構造登録者

Wang, C.,Vorobiev, S.M.,Vernon, R.M.,Khazanov, N.,Senderowitz, H.,Forman-Kay, J.D.,Hunt, J.F. (登録日: 2019-10-03, 公開日: 2020-10-07, 最終更新日: 2023-10-11)

• 主引用文献: Wang, C.,Vorobiev, S.,Vernon, R.M.,Khazanov, N.,Senderowitz, H.,Forman-Kay, J.D.,Hunt, J.F.; A thermodynamically stabilized form of the second nucleotide binding domain from human CFTR shows a catalytically inactive conformation; To Be Published,

実験手法

X-RAY DIFFRACTION (2.693 Å)