6UIP

DYRK1A Kinase Domain in Complex with a 6-azaindole Derivative, GNF2133.

6UIP の概要

• エントリーDOI: 10.2210/pdb6uip/pdb
• 分子名称: Dual specificity tyrosine-phosphorylation-regulated kinase 1A, 4-ethyl-N-{4-[1-(oxan-4-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]pyridin-2-yl}piperazine-1-carboxamide (2 entities in total)
• 機能のキーワード: kinase, inhibitor, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 127548.21

構造登録者

DiDonato, M.,Spraggon, G. (登録日: 2019-10-01, 公開日: 2020-03-04, 最終更新日: 2023-11-15)

• 主引用文献: Liu, Y.A.,Jin, Q.,Zou, Y.,Ding, Q.,Yan, S.,Wang, Z.,Hao, X.,Nguyen, B.,Zhang, X.,Pan, J.,Mo, T.,Jacobsen, K.,Lam, T.,Wu, T.Y.,Petrassi, H.M.,Bursulaya, B.,DiDonato, M.,Gordon, W.P.,Liu, B.,Baaten, J.,Hill, R.,Nguyen-Tran, V.,Qiu, M.,Zhang, Y.Q.,Kamireddy, A.,Espinola, S.,Deaton, L.,Ha, S.,Harb, G.,Jia, Y.,Li, J.,Shen, W.,Schumacher, A.M.,Colman, K.,Glynne, R.,Pan, S.,McNamara, P.,Laffitte, B.,Meeusen, S.,Molteni, V.,Loren, J.; Selective DYRK1A Inhibitor for the Treatment of Type 1 Diabetes: Discovery of 6-Azaindole Derivative GNF2133.; J.Med.Chem., 63:2958-2973, 2020; PubMed: 32077280; DOI: 10.1021/acs.jmedchem.9b01624

実験手法

X-RAY DIFFRACTION (3.7 Å)