6UHY
WDR5 in complex with Myc site fragment inhibitor
Summary for 6UHY
Entry DOI | 10.2210/pdb6uhy/pdb |
Descriptor | WDR5, 1-cyclohexyl-1H-benzimidazole-5-carboxylic acid (3 entities in total) |
Functional Keywords | wdr5, myc, inhibitor, complex, transcription |
Biological source | Homo sapiens |
Total number of polymer chains | 2 |
Total formula weight | 67472.62 |
Authors | Wang, F.,Fesik, S.W. (deposition date: 2019-09-29, release date: 2020-04-15, Last modification date: 2024-03-13) |
Primary citation | Chacon Simon, S.,Wang, F.,Thomas, L.R.,Phan, J.,Zhao, B.,Olejniczak, E.T.,Macdonald, J.D.,Shaw, J.G.,Schlund, C.,Payne, W.,Creighton, J.,Stauffer, S.R.,Waterson, A.G.,Tansey, W.P.,Fesik, S.W. Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design. J.Med.Chem., 63:4315-4333, 2020 Cited by PubMed: 32223236DOI: 10.1021/acs.jmedchem.0c00224 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.26 Å) |
Structure validation
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