Crystal structure of the Fc fragment of PF06438179/GP1111 an infliximab biosimilar in a C-centered orthorhombic crystal form, Lot A

Summary for 6UGW

DescriptorPF-06438179/GP1111 Fc, ZINC ION, ACETATE ION, ... (9 entities in total)
Functional Keywordsantibody, biologic, biosimilar, infliximab, fragment crystallizable, immune system
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total molecular weight30164.93
Mayclin, S.J.,Edwards, T.E. (deposition date: 2019-09-26, release date: 2019-11-13, Last modification date: 2020-02-12)
Primary citation
Lerch, T.F.,Sharpe, P.,Mayclin, S.J.,Edwards, T.E.,Polleck, S.,Rouse, J.C.,Zou, Q.,Conlon, H.D.
Crystal Structures of PF-06438179/GP1111, an Infliximab Biosimilar.
BioDrugs, 34:77-87, 2020
PubMed: 31650490 (PDB entries with the same primary citation)
DOI: 10.1007/s40259-019-00390-1
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.21830 1.1% 1.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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