6UGR
Human Carbonic Anhydrase 2 complexed with SB4-208
Summary for 6UGR
Entry DOI | 10.2210/pdb6ugr/pdb |
Descriptor | Carbonic anhydrase 2, ZINC ION, 7-fluoro-1lambda~6~,2,4-benzothiadiazine-1,1,3(2H,4H)-trione, ... (4 entities in total) |
Functional Keywords | cyclical sulfonamide, inhibitor, lyase, lyase-lyase inhibitor complex, lyase/lyase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 29214.24 |
Authors | Murray, A.B.,Lomelino, C.L.,McKenna, R. (deposition date: 2019-09-26, release date: 2019-12-18, Last modification date: 2023-10-11) |
Primary citation | Bua, S.,Lomelino, C.,Murray, A.B.,Osman, S.M.,ALOthman, Z.A.,Bozdag, M.,Abdel-Aziz, H.A.,Eldehna, W.M.,McKenna, R.,Nocentini, A.,Supuran, C.T. "A Sweet Combination": Developing Saccharin and Acesulfame K Structures for Selectively Targeting the Tumor-Associated Carbonic Anhydrases IX and XII. J.Med.Chem., 63:321-333, 2020 Cited by PubMed: 31794211DOI: 10.1021/acs.jmedchem.9b01669 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.307 Å) |
Structure validation
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