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6UE6

PWWP1 domain of NSD2 in complex with MR837

Summary for 6UE6
Entry DOI10.2210/pdb6ue6/pdb
DescriptorHistone-lysine N-methyltransferase NSD2, 4-cyano-N-cyclopropyl-N-[(thiophen-2-yl)methyl]benzamide, UNKNOWN ATOM OR ION (3 entities in total)
Functional Keywordsmethyltransferase, structural genomics, structural genomics consortium, sgc, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains8
Total formula weight130790.79
Authors
Liu, Y.,Tempel, W.,De Freitas, R.F.,Schapira, M.,Brown, P.J.,Bountra, C.,Edwards, A.M.,Arrowsmith, C.H.,Min, J.,Structural Genomics Consortium (SGC) (deposition date: 2019-09-20, release date: 2019-11-13, Last modification date: 2023-10-11)
Primary citationFerreira de Freitas, R.,Liu, Y.,Szewczyk, M.M.,Mehta, N.,Li, F.,McLeod, D.,Zepeda-Velazquez, C.,Dilworth, D.,Hanley, R.P.,Gibson, E.,Brown, P.J.,Al-Awar, R.,James, L.I.,Arrowsmith, C.H.,Barsyte-Lovejoy, D.,Min, J.,Vedadi, M.,Schapira, M.,Allali-Hassani, A.
Discovery of Small-Molecule Antagonists of the PWWP Domain of NSD2.
J.Med.Chem., 64:1584-1592, 2021
Cited by
PubMed: 33522809
DOI: 10.1021/acs.jmedchem.0c01768
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

217705

數據於2024-03-27公開中

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