6UBI

N123-VRC34.05 HIV neutralizing antibody in complex with HIV fusion peptide residue 512-519

6UBI の概要

• エントリーDOI: 10.2210/pdb6ubi/pdb
• 分子名称: VRC34.05 heavy chain, VRC34.05 light chain, HIV fusion peptide 512-519, ... (4 entities in total)
• 機能のキーワード: hiv, neutralizing, antibody, fusion peptide, immune system-viral protein, immune system-viral protein complex, immune system/viral protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 97006.31

構造登録者

Xu, K.,Liu, K.,Kwong, P.D. (登録日: 2019-09-11, 公開日: 2020-03-18, 最終更新日: 2020-04-22)

• 主引用文献: Shen, C.H.,DeKosky, B.J.,Guo, Y.,Xu, K.,Gu, Y.,Kilam, D.,Ko, S.H.,Kong, R.,Liu, K.,Louder, M.K.,Ou, L.,Zhang, B.,Chao, C.W.,Corcoran, M.M.,Feng, E.,Huang, J.,Normandin, E.,O'Dell, S.,Ransier, A.,Rawi, R.,Sastry, M.,Schmidt, S.D.,Wang, S.,Wang, Y.,Chuang, G.Y.,Doria-Rose, N.A.,Lin, B.,Zhou, T.,Boritz, E.A.,Connors, M.,Douek, D.C.,Karlsson Hedestam, G.B.,Sheng, Z.,Shapiro, L.,Mascola, J.R.,Kwong, P.D.; VRC34-Antibody Lineage Development Reveals How a Required Rare Mutation Shapes the Maturation of a Broad HIV-Neutralizing Lineage.; Cell Host Microbe, 27:531-, 2020; PubMed: 32130953; DOI: 10.1016/j.chom.2020.01.027

実験手法

X-RAY DIFFRACTION (1.903 Å)