6U9M

MLL1 SET N3861I/Q3867L bound to inhibitor 16 (TC-5109)

Summary for 6U9M

• Entry DOI: 10.2210/pdb6u9m/pdb
• Related: 6U9K
• Descriptor: Histone-lysine N-methyltransferase, ZINC ION, 5'-{[(3S)-3-amino-3-carboxypropyl]({1-[(thiophen-2-yl)methyl]azetidin-3-yl}methyl)amino}-5'-deoxyadenosine, ... (5 entities in total)
• Functional Keywords: transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 37774.53

Authors

Petrunak, E.M.,Stuckey, J.A. (deposition date: 2019-09-09, release date: 2020-07-01, Last modification date: 2023-10-11)

• Primary citation: Chern, T.R.,Liu, L.,Petrunak, E.,Stuckey, J.A.,Wang, M.,Bernard, D.,Zhou, H.,Lee, S.,Dou, Y.,Wang, S.; Discovery of Potent Small-Molecule Inhibitors of MLL Methyltransferase.; Acs Med.Chem.Lett., 11:1348-1352, 2020; PubMed: 32551023; DOI: 10.1021/acsmedchemlett.0c00229

Experimental method

X-RAY DIFFRACTION (2.05 Å)