6U9M
MLL1 SET N3861I/Q3867L bound to inhibitor 16 (TC-5109)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Histone-lysine N-methyltransferase | polymer | 158 | 18243.2 | 2 | UniProt (B4DIJ7) Pfam (PF00856) UniProt (by SIFTS) (Q03164) | Homo sapiens (Human) | |
| 2 | C, E (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D, G (A, B) | 5'-{[(3S)-3-amino-3-carboxypropyl]({1-[(thiophen-2-yl)methyl]azetidin-3-yl}methyl)amino}-5'-deoxyadenosine | non-polymer | 532.6 | 2 | Chemie (Q2M) | |||
| 4 | F (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | H, I (A, B) | water | water | 18.0 | 164 | Chemie (HOH) |
Sequence modifications
A, B: 3813 - 3969 (UniProt: B4DIJ7)
| PDB | External Database | Details |
|---|---|---|
| Ser 3812 | - | expression tag |
| Ile 3861 | Asn 215 | engineered mutation |
| Leu 3867 | Gln 221 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 36486.4 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1288.1 | |
| All* | Total formula weight | 37774.5 |
