6U8R

Human IMPDH2 treated with ATP, IMP, and NAD+. Bent (1/4 compressed, 3/4 extended) segment reconstruction.

Summary for 6U8R

• Entry DOI: 10.2210/pdb6u8r/pdb
• Related: 6U8E 6U8N
• EMDB information: 20687 20688 20690
• Descriptor: Inosine-5'-monophosphate dehydrogenase 2, INOSINIC ACID, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... (4 entities in total)
• Functional Keywords: metabolism, filament, allostery, adenine, guanine, biosynthetic protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 16
• Total formula weight: 919895.94

Authors

Johnson, M.C.,Kollman, J.M. (deposition date: 2019-09-05, release date: 2020-03-25, Last modification date: 2024-03-20)

• Primary citation: Johnson, M.C.,Kollman, J.M.; Cryo-EM structures demonstrate human IMPDH2 filament assembly tunes allosteric regulation.; Elife, 9:-, 2020; PubMed: 31999252; DOI: 10.7554/eLife.53243

Experimental method

ELECTRON MICROSCOPY (3.91 Å)