6U8H

BRD2-BD1 in complex with the cyclic peptide 3.2_2

6U8H の概要

• エントリーDOI: 10.2210/pdb6u8h/pdb
• 分子名称: Bromodomain-containing protein 2, cyclic peptide 3.2_2, IODIDE ION, ... (7 entities in total)
• 機能のキーワード: bet, bromodomain, macrocyclic peptide, brd2, inhibitor, rapid, transcription-inhibitor complex, transcription, transcription/inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 19150.84

構造登録者

Patel, K.,Walshe, J.L.,Walport, L.J.,Mackay, J.P. (登録日: 2019-09-05, 公開日: 2020-08-19, 最終更新日: 2023-11-15)

• 主引用文献: Patel, K.,Walport, L.J.,Walshe, J.L.,Solomon, P.D.,Low, J.K.K.,Tran, D.H.,Mouradian, K.S.,Silva, A.P.G.,Wilkinson-White, L.,Norman, A.,Franck, C.,Matthews, J.M.,Guss, J.M.,Payne, R.J.,Passioura, T.,Suga, H.,Mackay, J.P.; Cyclic peptides can engage a single binding pocket through highly divergent modes.; Proc.Natl.Acad.Sci.USA, 117:26728-26738, 2020; PubMed: 33046654; DOI: 10.1073/pnas.2003086117

実験手法

X-RAY DIFFRACTION (2.07 Å)