6U7C

Human GRK2 in complex with Gbetagamma subunits and CCG258747

Summary for 6U7C

• Entry DOI: 10.2210/pdb6u7c/pdb
• Descriptor: Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• Functional Keywords: g-protein coupled receptor kinase, kinase inhibitor, signaling protein, transferase-signaling protein complex, transferase/signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 125481.49

Authors

Bouley, R.,Tesmer, J.J.G. (deposition date: 2019-09-02, release date: 2020-04-15, Last modification date: 2023-10-11)

• Primary citation: Bouley, R.A.,Weinberg, Z.Y.,Waldschmidt, H.V.,Yen, Y.C.,Larsen, S.D.,Puthenveedu, M.A.,Tesmer, J.J.G.; A New Paroxetine-Based GRK2 Inhibitor Reduces Internalization of themu-Opioid Receptor.; Mol.Pharmacol., 97:392-401, 2020; PubMed: 32234810; DOI: 10.1124/mol.119.118661

Experimental method

X-RAY DIFFRACTION (2.44 Å)