6U7C

Human GRK2 in complex with Gbetagamma subunits and CCG258747

6U7C の概要

• エントリーDOI: 10.2210/pdb6u7c/pdb
• 分子名称: Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• 機能のキーワード: g-protein coupled receptor kinase, kinase inhibitor, signaling protein, transferase-signaling protein complex, transferase/signaling protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 125481.49

構造登録者

Bouley, R.,Tesmer, J.J.G. (登録日: 2019-09-02, 公開日: 2020-04-15, 最終更新日: 2023-10-11)

• 主引用文献: Bouley, R.A.,Weinberg, Z.Y.,Waldschmidt, H.V.,Yen, Y.C.,Larsen, S.D.,Puthenveedu, M.A.,Tesmer, J.J.G.; A New Paroxetine-Based GRK2 Inhibitor Reduces Internalization of themu-Opioid Receptor.; Mol.Pharmacol., 97:392-401, 2020; PubMed: 32234810; DOI: 10.1124/mol.119.118661

実験手法

X-RAY DIFFRACTION (2.44 Å)