6U6B
Structure of human DNA polymerase beta misinserting dAMPNPP opposite the 5'G of the cisplatin Pt-GG intrastrand crosslink with Manganese in the active site
Summary for 6U6B
Entry DOI | 10.2210/pdb6u6b/pdb |
Related | 6U2O |
Descriptor | DNA polymerase beta, DNA (5'-D(*CP*CP*CP*AP*CP*GP*GP*CP*CP*CP*AP*TP*CP*AP*CP*C)-3'), DNA (5'-D(P*GP*GP*TP*GP*AP*TP*GP*GP*GP*C)-3'), ... (9 entities in total) |
Functional Keywords | polymerase, cisplatin, mismatch, pt-gg, transferase, transferase-dna complex, transferase/dna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 48653.97 |
Authors | Ouzon-Shubeita, H.,Vilas, C.K.,Lee, S. (deposition date: 2019-08-29, release date: 2020-09-09, Last modification date: 2023-10-11) |
Primary citation | Ouzon-Shubeita, H.,Vilas, C.K.,Lee, S. Structural insights into the promutagenic bypass of the major cisplatin-induced DNA lesion. Biochem.J., 477:937-951, 2020 Cited by PubMed: 32039434DOI: 10.1042/BCJ20190906 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.108 Å) |
Structure validation
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