6U6B
Structure of human DNA polymerase beta misinserting dAMPNPP opposite the 5'G of the cisplatin Pt-GG intrastrand crosslink with Manganese in the active site
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA polymerase beta | polymer | 335 | 38241.7 | 1 | UniProt (P06746) Pfam (PF14716) Pfam (PF10391) Pfam (PF14792) Pfam (PF14791) | Homo sapiens (Human) | |
| 2 | B (T) | DNA (5'-D(*CP*CP*CP*AP*CP*GP*GP*CP*CP*CP*AP*TP*CP*AP*CP*C)-3') | polymer | 16 | 4749.1 | 1 | Homo sapiens | ||
| 3 | C (P) | DNA (5'-D(P*GP*GP*TP*GP*AP*TP*GP*GP*GP*C)-3') | polymer | 10 | 3141.1 | 1 | Homo sapiens | ||
| 4 | D (D) | DNA (5'-D(P*GP*TP*GP*GP*G)-3') | polymer | 5 | 1576.1 | 1 | Homo sapiens | ||
| 5 | E, F (A) | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) | |||
| 6 | G, H (A) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 7 | I (A) | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine | non-polymer | 490.2 | 1 | Chemie (DZ4) | |||
| 8 | J (T) | Cisplatin | non-polymer | 300.0 | 1 | Chemie (CPT) | |||
| 9 | K, L, M, N (A, T, P, D) | water | water | 18.0 | 17 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 47707.9 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 946.1 | |
| All* | Total formula weight | 48654.0 |
